In this commentary, we outline the strategies and targets currently adopted in developing a vaccine against SARS-CoV-2. Based on previous evidence and experience with SARS and MERS, the primary focus has been the Spike protein, which has proved to be highly immunogenic and capable of eliciting a robust neutralizing response.

As it rapidly became the main target of neutralizing antibodies and the focus of therapeutic and vaccine design, the Spike protein is considered as an ideal target for COVID-19 immunotherapy.

Full article: SARS-CoV-2 SPIKE PROTEIN: an optimal immunological target for vaccines