Human Tumor Xenograft Model

For years, mouse tumor models have continuously been used to verify the in vivo efficacy of novel anti-tumor therapeutics in advance of clinical research and testing in humans.

Xenograft tumor models are usually established by subcutaneous inoculation of a certain number of tumor cells into the flank of mouse. The mouse strains used (e.g. nude or SCID immunodeficient mice) show significant high acceptance rate for xenografts, making them ideal implement for in vivo culture of human tumors. They are normally used to discovery therapeutic schedules, drug dosage and routes of administration, for the sake of maximizing anti-tumor efficacy and therapeutic window.


STUDY ENDPOINT
  • Biomarker screening sampling or evaluation
  • Blood collections and analysis
  • Pharmacokinetic or bioavailability sampling  and analysis
  • Tissue collections
  • Histopathologic analysis
VALIDATION DATA
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Tumor kinetics. Tumors were measured with a caliper at the indicate time point. The curves indicate the average and standard error of mice/group. Example of efficacy study for combination design.

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TNBS-Induced Colitis Model

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Ligature-Induced Periodontitis Model

Ligature-Induced Periodontitis Model

Diet-Induced Obesity Model

Diet-Induced Obesity Model

Human Tumor Xenograft Model

Human Tumor Xenograft Model

ANIMAL FACILITY

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Takis is a biotech dedicated to cancer research. Our primary objective is the development of innovative therapies based on the principle that our immune system can be “instructed” to recognize the tumor and reject it as a foreign entity.