Diet-Induced Obesity Model

The primary cause of obesity is excessive caloric intake with too little exercise. Dietary-induced obesity in mice usually involves a high-fat diet and is translatable to the human population. Dietary-induced obese mice are well-established animal models of obesity. Male C57BL/6 mice 9 weeks old, are fed on 60% kcal high fat irradiated diet for 8 weeks. Control males are housed in the same location and are fed with Standard chow.


STUDY ENDPOINT
  • Food intake measurement
  • Body weight measurement
  • Body mass calculation (Lee’s Index)
  • Blood collections and serum biochemical analysis
  • Stool collections for Next-Generation DNA Sequencing technology (NGS) analysis of microbiota
  • Tissue collections
  • Histopathologic analysis
VALIDATION DATA
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Representative H&E staining of liver section.

Quantification of liver TG level and Liver scoring (Brunt scoring.

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Blood Triglycerides level obesity-associated.

Dextran Sulfate Sodium-Induced Colitis Model

Dextran Sulfate Sodium-Induced Colitis Model

TNBS-Induced Colitis Model

TNBS-Induced Colitis Model

Ligature-Induced Periodontitis Model

Ligature-Induced Periodontitis Model

Diet-Induced Obesity Model

Diet-Induced Obesity Model

Human Tumor Xenograft Model

Human Tumor Xenograft Model

ANIMAL FACILITY

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Takis is a biotech dedicated to cancer research. Our primary objective is the development of innovative therapies based on the principle that our immune system can be “instructed” to recognize the tumor and reject it as a foreign entity.