Dextran Sulfate Sodium-Induced Colitis Model

Dextran Sulfate Sodium (DSS) is a sulfated polysaccharide with anticoagulant properties to induce colitis. It is believed that DSS is directly toxic to gut epithelial cells of the basal crypts and thus harm the integrity of the mucosal barrier. The clinical observation of DSS treated animals are very similar to human IBD pathologies.


STUDY ENDPOINT
  • MPO levels
  • DAI and Macroscopic scores
  • Cytokine analysis and other inflammatory markers (TNFa, IL-1b, SAA, KC)
  • Blood collections and analysis (Fe2+ and Hemoglobin)
  • Stool collections (NGS analysis of microbiota)
  • Tissue collections
  • Intestinal permeability (FITC-Dextran)
  • Histopathologic analysis
VALIDATION DATA
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3,5% DSS in drinking water induced clinical signs of IBD such as body weight loss and colon shortening


Dextran Sulfate Sodium-Induced Colitis Model

Dextran Sulfate Sodium-Induced Colitis Model

TNBS-Induced Colitis Model

TNBS-Induced Colitis Model

Ligature-Induced Periodontitis Model

Ligature-Induced Periodontitis Model

Diet-Induced Obesity Model

Diet-Induced Obesity Model

Human Tumor Xenograft Model

Human Tumor Xenograft Model

ANIMAL FACILITY

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Takis is a biotech dedicated to cancer research. Our primary objective is the development of innovative therapies based on the principle that our immune system can be “instructed” to recognize the tumor and reject it as a foreign entity.