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Takis and Evvivax developing a 2019-nCoV Coronavirus vaccine

Rome, 27 January 2020 - Takis and Evvivax, two biotechnology companies present in the science park of Castel Romano, Rome announce their commitment for the development of innovative vaccines against 2019-nCoV, the new coronavirus originating in Wuhan, China. To date, the virus has caused 81 deaths and over 2,800 known infections and is rapidly expanding in various countries.


"This is a worldwide emergency to which Takis researchers can and must contribute" - says Luigi Aurisicchio, CEO / CSO of the two companies - "We will immediately make available our skills gained for the development of vaccines against Cancer and other infectious diseases to fight the spread of this coronavirus ". Takis and Evvivax have developed vaccines based on genetic technologies capable of inducing powerful immune responses. "Our technologies are based on genetic engineering techniques and on the use of viruses and DNA fragments that can be used both for gene therapy and for vaccination" - says Emanuele Marra, Director of the Infectious Diseases Area at Takis. “To obtain antibodies capable of neutralizing pathogens, it is essential to use particularly effective technologies. At Takis, thanks to genetic vaccination, we have generated dozens of antibodies capable of neutralizing viruses and pathogenic bacteria "- continues Giuseppe Roscilli, Antibody Area Director. "In various clinical studies conducted in Italy and the USA, our veterinary vaccines have induced a powerful immune response and prolonged the survival of dogs with cancer, which like us humans develop it with high frequency. Even against zoonoses, that is, infectious diseases that are transmitted from animals to humans and vice versa, we can use the same type of approach. "- declares Dr. Antonella Conforti, Director at Evvivax.

Genetic vaccination is therefore the basis for the development of the 2019-nCoV vaccine at Takis. “Coronavirus biology and the availability of the 2019-nCoV genome sequence are all the information we need for vaccine design. The development of the methods and the experimentation will be fundamental to get to human clinical trials as soon as possible "- says Fabio Palombo, Immunology and Cancer Vaccines Area – NeoMatrix Director.

"Thanks to the experience of our scientists, Takis and Evvivax are technologically competitive at an international level and can make their contribution to this Health emergency with the internal resources currently available. However, scientific research requires important investments and it is essential to obtain financing and / or collaborations with large companies as soon as possible that allow us to develop the 2019-nCoV vaccine as quickly as necessary. "- concludes Luigi Aurisicchio.
The race against the virus has started.

For more information: www.takisbiotech.it and www.evvivax.com


Visualization of 2019-nCoV with Transmission Electron Microscopy.

Negative-stained 2019-nCoV particles are shown in Panel A, and 2019-nCoV particles in the human airway epithelial cell ultrathin sections are shown in Panel B.

 

Trazimab as a new promising approach to treat invasive Aspergillosis

Takis is proud to announce very promising results achieved with Trazimab, a monoclonal antibody against a new target expressed by Aspergillus fumigatus, a fungus which causes Aspergillosis, a rare and deadly disease.

 

There has been in increase in the number of projects for the development of biotech drugs against infections caused by the fungus Aspergillus: that is a promising field of research, with Takis company at the forefront. This is thanks to an experienced team of researchers who are dedicated to identifying new molecular targets against which to develop the drugs of the future. The next goal for Takis is the production of Trazimab, a monoclonal antibody for the treatment of Aspergillus infections. The new therapeutic approach could prove to be effective in particular against invasive pulmonary aspergillosis, a respiratory infection that is affecting more and more people around the world and for which current drugs are likely to be inadequate.

Among the infections caused by fungi of the genus Aspergillus, invasive aspergillosis is perhaps the most relevant, with 200,000 cases per year worldwide and a mortality rate that despite treatments remains between 25% and 80%. Whereas it does not affect immunocompetent individuals, invasive aspergillosis is extremely dangerous, even lethal for immunocompromised individuals.

 


There are many immunosuppressed patients, for example those taking immunosuppressive drugs following a transplant or those undergoing chemotherapy or radiotherapy to treat cancer. For these people, the only hope of treatment, until recently, were antifungal drugs, in particular azoles. But they are no longer enough, because of the onset of multi-resistant strains both in clinical settings and in the environment due to the abuse of fungicide in agriculture. They are increasingly widespread and require the development of innovative therapeutic strategies.
The hope against Aspergillus fumigatus today comes from biotechnology. Within the Trazimab project funded by the Campania region, Takis is developing biotechnological drugs against Aspergillus, such as monoclonal antibodies. This represents a potential alternative to traditional therapy, which in addition to dealing with the widespread phenomenon of drug-resistance, is also associated with important side effects on the kidneys and liver. Thanks to decades of experience in the production of antibodies and in vivo studies, the Takis team aims to transform the treatment of invasive aspergillosis with an innovative antibody, directed against a still unexplored molecular target, which promises to open a new way in the fight against Aspergillus.
Monoclonal antibodies are today one of the most avant-garde therapeutic approaches for the treatment of cancer, but their use is beginning to extend also to infectious diseases. This is thanks to their ability to recognize specific molecular targets with extreme precision, reducing side effects and maximizing efficacy. “We believe that the development of Trazimab could be a great opportunity for the use of monoclonal antibodies for a disease, such as Invasive Pulmonary Aspergillosis, in which small molecules still represent the gold standard” said Emanuele Marra, Director of Infectious diseases at Takis,“I also consider that the methodology used for the development of this antibody could facilitate the production of specific antibodies against fungal proteins and not just saccharide components”

2 December 2019 - Takis second Biotech in Europe at EIT Health Catapult Final!

Takis second Biotech in Europe at EIT Health Catapult Final!

Takis second Biotech in Europe at EIT Health Catapult Final


Paris, 2 December, 2019 – NeoMatrix, a neoantigen-based cancer vaccine based on Precision Immunology has been awarded second among the best Biotech companies in Europe. The journey started this summer, when a though selection of 150 companies led to a list of 7 finalists.

“The EIT Health Catapult competition was a great experience and most importantly validated NeoMatrix concept and business model” said Dr. Fabio Palombo, Director of NeoMatrix. “We have all the tools to make our dream real: provide new cures to cancer patients.”

“This is an fantastic recognition of our work and our ideas” said Luigi Aurisicchio, CEO/CSO. “We are more and more motivated to move forward NeoMatrix to clinical trial. In Paris we had the opportunity to meet many other stakeholders, learn each other and above all to establish a great network for future collaborations. ”
Are you ready to be "catapulted" in the Future of Cancer Therapy?

For more information please see our NeoMatrix web page

Check out all EHC finalists at: FINALISTS EHC 2019 – BIOTECH HEALTH Category

2-3 December 2019 - PARIS - European EIT Health Biotech Final: Forza Takis and Forza Italia!

NeoMatrix Personalized Cancer Vaccine Program at EIT Health Final in Paris, 2-3 December 2019

NEOMATRIX

Takis among the 7 European Finalists at EIT Health Summit


Paris, 2 December, 2019 – Takis, an Italian Biotech Company leader in Gene Therapy, Cancer Vaccines and generation of monoclonal antibodies is proud to announce its participation at the

eit Healt Summit 2019

the place where collective ideas transform the future of healthcare.

Takis S.R.L. will present NeoMatrix, a neoantigen-based cancer vaccine, as a proof-of-concept of personalized immunology. NeoMatrix starts from tumor biopsy  and gets to the manufacturing of a personalized cancer vaccine in 5 weeks.

“We are proud to have been selected among the finalists in this important European competition. Not only as Takis Biotech, but also as the only Italian company among incredible companies with brilliant ideas and teams able to create new opportunities for patients” said Luigi Aurisicchio, CEO/CSO.

“We know that immune system has a key role in fighting cancer” said Dr. Fabio Palombo, Leader and Champion of NeoMatrix. “Thanks to a deep knowledge of cancer immunobiology and cutting-edge vaccination technologies we have now the tools to provide precision therapies to human patients able to complement current standard of care.”

Stay tuned for the competition!

 

For more information please see our NeoMatrix web page

Check out all EHC finalists at: FINALISTS EHC 2019

Hamburg, Germany – November 13-15 Engage with Takis Biotech at BIO-EUROPE 2019

TDr Luigi Aurisicchio, CEO/CSO at Takis and Evvivax, will attend Bioeurope 2019. As Europe's largest life science partnering conference, BIO-Europe offers countless opportunities to engage with global life science partners. As key biotech, Takis will discuss with potential partners a number of available opportunities and services. The event brings together makers and investors within the life science industry to debate and to drive forward leading innovation.



This is an excellent opportunity to discuss Takis pipeline in one-to-one network meetings. Book your meeting with Luigi now!

To learn more: https://ebdgroup.knect365.com/bioeurope/?_ga=2.222724123.104266260.1571669222-1279262257.1532011842

26 September 2019 - Genomics and personalized medicine. Takis, the Italian excellence in biotechnology, challenges Europe!

The company of the Tecnopolo di Castel Romano in Rome is among the 7 finalists of the European Health Catapult. The final will be held on 2 and 3 December in Paris.

26 September, ROME - Takis with its advanced projects presented a personalized therapeutic vaccine against cancer at the European Health Catapult Initiative earning its place in the final. A result achieved thanks to the creation of a personalized therapeutic vaccine against cancer. It is therefore a new challenge that aims at personalized medicine, genomics and cellular therapies that many people see as a necessary path on which to invest.


The genome of each tumor, in fact, presents mutations that differ from patient to patient and generate abnormal proteins called neo-antigens, absent in healthy cells. The vaccine designed by Takis instructs the cells of the immune system to recognize tumor neo-antigens and to destroy only the cells that express them. But since every tumor is different, each patient needs a tailored therapy: the starting point is the sequencing of the tumor genome, which helps the researchers to build an ad hoc vaccine.

This is an innovative project, which Takis researchers are pursuing with competence and enthusiasm. And that at European Health Catapult, in which 42 start-ups participated in Europe, has already captured the interest of investors, confirming once again the excellence of Italian research in the oncology field.

"We are proud of this result - said Luigi Aurisicchio, CEO of Takis -. In recent years we have undertaken many projects and we have dedicated ourselves to developing increasingly targeted and effective therapies against cancer. The merit is, above all, of our researchers, who put passion into what we do day after day to help patients in oncology ".

Fabio Palombo, head of the research program, is of the same opinion: "Thanks to the growing knowledge in Immuno-Oncology, to the Next Generation Sequencing and to ever more effective technologies, it is now possible to think of approaches to personalized medicine inconceivable until a few years ago. And we Italians with our ideas and our imagination, we can make a huge contribution to this constantly evolving field ".

With his experience in innovative cancer therapies, Takis is the only Italian company to have achieved this goal, proving to be among the 7 best biotech companies in Europe. Thanks to an intense research activity, which has succeeded in intercepting the most advanced topics in the fight against cancer in recent years. Such as immunotherapy, which uses the immune system to fight cancer, giving life to potentially more effective therapies than traditional ones, and above all more targeted. The scientific production of Takis, in fact, appears to be increasingly oriented towards the future, which is that of precision medicine and tailored to the patient. A possibility that today, thanks to in-depth knowledge of the human genome, is becoming more and more concrete.